The prevalence of breast cancer continues to rise, making them one of the most common diseases worldwide. In response, we have focused on inhibiting key proteins associated with this disease, specifically PTPs, PTP1B, and ABCG2. Our study began by examining over 23 indigenous plants from Chlef, Algeria, ultimately selecting fenugreek, date seeds, and mandarin peel for further analysis. A pharmacoinformatics study was conducted on 11 molecules from a pool of 75, demonstrating the potential inhibitory effects of rutin, Lutein, and naringin. Specifically, rutin showed an inhibitory interaction with PTPs, forming 1 amino acid bonds with a binding energy of ∆G = -5.3358 kcal/mol, while Naringin interacted with PTP1B, forming 3 amino acid bonds with a binding energy of ∆G = -7.2124 kcal/mol. Lutein formed 0 bonds with ABCG2, with a binding energy of ∆G = -6.5143 kcal/mol. The binding energy analysis of Tamoxifen across different protein targets shows varying degrees of interaction. The highest binding affinity is observed with 6VXI (-5.51 kcal/mol), followed by IXBO (-5.19 kcal/mol), while the weakest interaction occurs with 3I2B (-4.93 kcal/mol).

Background: Psychotropic drugs used to manage mental disorders affect oral health. The mechanism of action of these drugs differs from one therapeutic class to another. Objectives: to determine the side effects of psychotropic drugs on the oral health of pediatric patients with psychiatric disorders, to determine their care needs and to describe mechanismS of action of psychotropic drugs. Methods: Sixty-one children with mental disorders, aged between four and twelve years (48 boys and 13 girls) and who were followed up in Child psychiatry department in Hedi Chaker University Hospital in Sfax, were selected. The control group consisted of 61 healthy children who were matched by age and gender. Each patient received a complete oral examination. The prevalence of caries, decayed, missing, and filled teeth (dmft/DMFT) index, oral hygiene and care needs were noted.  Results: The mean (dmft/DMFT) index of children with mental disorders was 2.13 while that of the control group was 1.21. The prevalence of caries was respectively 49.2% and 41% for the cases and controls. Sixty –five percent of children with mental disorders had gingivitis. The most common oral side effects were dyskinesia, hypersalivation, dysphagia, halitosis and bruxism. Conclusion: Patients with psychiatric disorders are vulnerable to any oral pathology due to a lack of hygiene and autonomy to which are added the side effects of psychotropic drugs. For these reasons, specific therapeutic and preventive strategies should be instituted and focused towards this special population.