Background: Scoliosis is defined as the lateral curvature of the spine in the upright position. It is a deformity affecting spine in all three planes. In most of the cases the exact cause of the scoliosis is unclear and is more commonly seen in girls in the adolescent age group. Adolescent idiopathic scoliosis presents with a deformity of the back, unequal shoulder levels, waistline asymmetry and a rib cage prominence. Objectives: The study’s primary objective was to find out the effectiveness of Schroth and Pilates exercises versus Schroth and Vojta therapy on Cobb angle, Angle of trunk rotation, Chest expansion and Quality of life among Adolescents with Idiopathic Scoliosis. Subjects and methods: A pre-test, post-test comparative study design was used .A criterion-based randomized sampling was used to recruit adolescents with Idiopathic scoliosis (N=30) and they were divided into two treatment groups by using lot method. GROUP A consisted of 15 adolescents and they received Schroth and Pilates exercises whereas GROUP B also consisted of 15 adolescents but they received Schroth and Vojta therapy. Both the groups received the interventions for 5 days in a week for 12 weeks. The efficacy of treatment for Cobb angle, Angle of trunk rotation, Chest expansion and Quality of life were measured through X-ray, Bunnell scoliometer, measuring tape and SRS-22r questionnaire respectively. Both paired and unpaired‘t’ test was employed to study the treatment effectiveness. A p-value<0.05 was considered ‘significant’.  Result: The resultant of this study shows that there were improvements in both the groups eventually but Group A, which was exposed to the treatment combinations of Schroth and Pilates exercises showed better improvement in Cobb angle (mean difference 19.13), Angle of trunk rotation (mean difference 5.33), Chest expansion at N1,N2,N3 level (mean difference 5.56, 5.3, 5.3 respectively) and Quality of life (mean difference 4.67) than the Group B, that was exposed to the treatment combinations of Schroth and Vojta therapy at 0.05 levels of significance. Conclusion: Both the groups showed significant improvement in Cobb angle, Angle of trunk rotation, Chest expansion and Quality of life after the application of Schroth and Pilates exercises for group A and Schroth and Vojta therapy for group B for a period of 12 weeks. But comparatively Group A (Schroth and Pilates exercises) showed significant improvement in Cobb angle, Angle of trunk rotation, Chest expansion and Quality of life than Group B (Schroth and Vojta therapy).  Clinical implications: Schroth and Pilates exercises is found to produce better improvement in Cobb angle, Angle of trunk rotation, Chest expansion and Quality of life when compared to Schroth and Vojta therapy in Adolescents with Idiopathic Scoliosis.