Background: - Emergence of oxacillin resistance is complicating the treatment of severe infections caused by resistant S. aureus strains. The detection of BORSA strains can influence the choice of antibiotics for the treatment. Aim and objectives: - Our study was aimed to study the prevalence and the antimicrobial susceptibility of BORSA strains. . Material and methods: A total 100 isolates of S. aureus from various clinical samples were used in this study which were identified using standard conventional methods. MRSA was carried out using Cefoxitin, Oxacillin Disk Diffusion Test and Detection of Mec A was done by PCR. Result: - we found 37% MRSA strains detected by Cefoxitin disk diffusion test. All these strains were MecA positive. 38 strains were Methicillin Sensitive Staphylococcus aureus (MSSA) by Cefoxitin disk diffusion test as well as genotypic methods. We found 25 % BORSA strains. Conclusion: - Therapeutic challenges posed by clinical infections caused by BORSA strains so we should continuously monitor the study on BORSA strains.