Background of The Study: Upper cross syndrome (UCS) is also referred to as proximal or shoulder girdle crossed syndrome. In upper cross syndrome, tightness of the upper trapezius and levator scapula on the dorsal side crosses with tightness of the pectoralis major and minor. Weakness of the deep cervical flexors ventrally crosses with weakness of the middle and lower trapezius. Objectives: The study’s primary objective was to find out the effectiveness of Mckenzie exercise and kinesiotaping on upper cross syndrome. Subjects and Methodology: This experimental study based on 15 subjects with upper cross syndrome was selected based on inclusion and exclusion criteria with the age of 20 to 35 years. The selected subjects were received McKenzie exercise and kinesiotaping. The subjects were received intervention progressively for 6 weeks. It is a simple experimental study with purposive sampling technique. Before starting the study, the pre score value of pain was measured by visual analogue scale (VAS). After 6 weeks the post score was measured by using same measurement tool and the data were recorded and analyzed using paired ‘t’ test. Results: The statistical analysis shows pre mean value and SD for pain was 6.8 and 0.86 and post mean value and SD for pain was 2.2 and 0.51 respectively. The statistical analysis of paired t value was 22.3 and the level of significance p<0.05 which that there was statistically improvement in the group. The statistical analysis shows pre mean value and SD for functional ability was 10.2 and 1.74 and post mean value and SD is 16.33 and 2.81 respectively. The statistical analysis of paired ‘t’ value is 7.16 and the level of significance p<0.05 which that there was statistically improvement in the group. Thus, the result state that there calculated ‘t’ values of pain and functional ability was greater than the table value showing. Conclusion: This study concluded that there was significant reduction in pain and improvement in functional ability after the application of McKenzie exercise and kinesiotaping in upper cross syndrome subjects. Clinical Implications: Mckenzie exercise and kinesiotaping is found to produce a significant effect to manage upper cross syndrome.