Pulpotomy, a name traditionally associated with pediatric dentistry, has recently garnered rekindled interest in endodontics, particularly for fully developed permanent teeth. While historically used primarily for primary and young permanent teeth, pulpotomy is now being extended to mature teeth with symptomatic or asymptomatic irreversible pulpitis. These advancements, driven by cutting-edge technologies, allow for better tooth preservation and improved treatment outcomes. Despite these developments, traditional root canal therapy remains complex and costly, especially in general practice where pulpectomy success rates have been suboptimal. The resurgence of pulpotomy in mature teeth aligns with the broader trend toward minimally invasive and patient-centered dental care. By combining modern diagnostic tools with advanced biomaterials, this well-established technique provides a conservative approach to treating pulp-related issues in mature dentition. Proper case selection, eagle’s eye diagnosis, operator skill, and long-term follow-up are very much crucial for successful pulpotomy procedures in the mature adult teeth.